IORT stands for IntraOperative RadioTherapy and TARGIT stands for TARGeted IntraOperative RadioTherapy. IORT is a technique of delivering radiotherapy directly to the tissues surrounding a cancer (also known as the tumour bed) after its surgical removal.
University Malaya Medical Centre acquired an IORT system called Intrabeam (Carl Zeiss®, Germany) in 2015. We are privileged to be able to offer this state-of-art technique to our patients. Your doctor will discuss about the if you are suitable for this treatment .
Many women with early breast cancer would require radiotherapy after surgery. This is usually delivered using External Beam RadioTherapy (EBRT). Treatment is started a few weeks after surgery or chemotherapy. It is given on a daily basis over 3-5 weeks. The whole breast tissue is usually treated in this technique.
TARGIT IORT delivers the radiotherapy directly to the breast tissue in a single treatment during surgery itself. Several studies in breast cancer have confirmed its benefit in patients with low risk disease. Studies are ongoing to confirm its role in patients with higher risk disease.
1) It allows direct radiation to the affected area therefore reducing some of the treatment side effects.
2) It avoids the gap between surgery and external beam breast radiotherapy. As it is given during surgery. This may prove treatment efficacy.
3) IORT is given as a single dose, while EBRT is given on a daily basis for a 3-5 weeks after surgery. Therefore the IORT treatment time is shorter and avoids prolonged daily visits to hospital.
4) Some patients will require IORT as the sole radiation treatment while other s may also need EBRT in addition to IORT. If EBRT is required , it is delivered after surgery and the total duration is limited to 3 weeks only as opposed to full EBRT course which involved approximately 5 weeks of therapy. Therefore , patients is as good as EBRT in reducing risk of caner recurrence.
5)Several studies have confirmed that TARGIT IORT is as good as EBRT in suitable patients.
6)A study showed that IORT alone may provide better cosmetic outcomes compared to EBRT.
1) Redness and soreness of the skin
3) Possible effect on wound healing (firmness of the scar)
4) Serious wound complications are rare
5) Possible effect on wound healing (firmness of the scar)
6) Serious wound complications are rare
The decision whether IORT is suitable for you will be decided by your team of doctors based on various factors. This will be discussed and explained to you.